What question did this study set out to answer?

The study aims to explore how pH influences the binding behavior of ipilimumab to CTLA-4.

May 6, 2026Physical Chemistry Chemical Physics0 citations

Computational Insights into the pH-Dependent Behavior of Ipilimumab-CTLA-4

WDWanda DestiaraniUniversity of Tsukuba KHKowit HengphasatpornUniversity of Tsukuba YSYasuteru ShigetaUniversity of Tsukuba

Key Points

The study aims to explore how pH influences the binding behavior of ipilimumab to CTLA-4.
Computational modeling analyses of pH-dependent interactions.
Evaluation of antibody binding affinities at varying pH levels.
Assessment of potential toxicity risks associated with binding.
Identified a significant pH sensitivity in ipilimumab's binding affinity to CTLA-4.
Demonstrated a reduction in on-target/off-tumor cardiotoxicity risk for engineered antibodies.

Abstract

Therapeutic antibodies face on-target/off-tumor toxicity, causing adverse effects such as cardiotoxicity, skin rashes, and organ inflammation. To mitigate these challenges, pH-dependent antibodies have been engineered to preferentially bind in the...

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