Computational Insights into the pH-Dependent Behavior of Ipilimumab-CTLA-4

Wanda Destiarani; Kowit Hengphasatporn; Yasuteru Shigeta; Ryuhei Harada

doi:10.1039/d5cp04018c

January 1, 2026Physical Chemistry Chemical Physics

Computational Insights into the pH-Dependent Behavior of Ipilimumab-CTLA-4

View Full Paper

Ask AI

Bookmark

Share

Key Points

The study aims to explore how pH influences the binding behavior of ipilimumab to CTLA-4.
Computational modeling analyses of pH-dependent interactions.
Evaluation of antibody binding affinities at varying pH levels.
Assessment of potential toxicity risks associated with binding.
Identified a significant pH sensitivity in ipilimumab's binding affinity to CTLA-4.
Demonstrated a reduction in on-target/off-tumor cardiotoxicity risk for engineered antibodies.

Implication

Computational analysis demonstrates pH-dependent binding of therapeutic antibodies, indicating reduced cardiotoxicity risk.

Abstract

Therapeutic antibodies face on-target/off-tumor toxicity, causing adverse effects such as cardiotoxicity, skin rashes, and organ inflammation. To mitigate these challenges, pH-dependent antibodies have been engineered to preferentially bind in the...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Destiarani et al. (2026) studied this question.

synapsesocial.com/papers/69fa8ef304f884e66b531558 https://doi.org/10.1039/d5cp04018c

View Full Paper

Ask AI

Bookmark

Share

Computational Insights into the pH-Dependent Behavior of Ipilimumab-CTLA-4

Key Points

Implication

Abstract

Discussion

Cite This Study

Computational Insights into the pH-Dependent Behavior of Ipilimumab-CTLA-4

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading