Binding Azaphilic Copper Radioisotopes with All-Nitrogen Macrocycles for Cancer Theranostics

Key Points

• This research aims to develop chelators for stable copper radioisotope complexes to enhance cancer theranostics.
• Synthesis of azaphilic macrocyclic chelators
• Evaluation of copper radioisotope binding affinity
• Assessment of radiopharmaceutical stability
• Demonstrated high thermodynamic stability of copper complexes
• Showed enhanced kinetic inertness for prolonged efficacy
• Improved imaging and therapy outcomes in cancer models