Binding Azaphilic Copper Radioisotopes with All-Nitrogen Macrocycles for Cancer Theranostics

Sara Franchi; Mattia Asti; Nóra May; Silvia Pozzo; Sofia Gama; Erika Ferrari; Laura Pigani; Christian Jentschel; Christin Neuber; Fabrizio Mancin; S. Stadlbauer; Klaus Kopka; Constantin Mamat; Helmut Maecke; Valerio Di Marco; Marianna Tosato

doi:10.1039/d6qi00856a

January 1, 2026Inorganic Chemistry FrontiersOpen Access

Binding Azaphilic Copper Radioisotopes with All-Nitrogen Macrocycles for Cancer Theranostics

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Key Points

This research aims to develop chelators for stable copper radioisotope complexes to enhance cancer theranostics.
Synthesis of azaphilic macrocyclic chelators
Evaluation of copper radioisotope binding affinity
Assessment of radiopharmaceutical stability
Demonstrated high thermodynamic stability of copper complexes
Showed enhanced kinetic inertness for prolonged efficacy
Improved imaging and therapy outcomes in cancer models

Implication

Theranostic agents improve cancer imaging and therapy through stable copper radiopharmaceuticals, suggesting enhanced treatment options.

Abstract

Copper radioisotopes constitute a true theranostic family, enabling cancer imaging and therapy with chemically identical metal-based radiopharmaceuticals. Developing chelators that provide copper complexes combining high thermodynamic stability, kinetic inertness, and...

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Cite This Study

Franchi et al. (2026) studied this question.

synapsesocial.com/papers/6a03cbbe1c527af8f1ecf6fa https://doi.org/10.1039/d6qi00856a

View Full Paper

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Binding Azaphilic Copper Radioisotopes with All-Nitrogen Macrocycles for Cancer Theranostics

Key Points

Implication

Abstract

Discussion

Cite This Study

Binding Azaphilic Copper Radioisotopes with All-Nitrogen Macrocycles for Cancer Theranostics

Key Points

Implication

Abstract

Discussion

Cite This Study

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