A Hybrid Pyridine-Thioether Macrocycle to Chelate Theranostic Copper and Silver Radioisotopes

Marianna Tosato; Fortuna Ponte; Sara Franchi; Nóra May; Mikael Jensen; Helmut Maecke; Valerio Di Marco; Laura Pigani; Erika Ferrari; Emilia Sicilia; Mattia Asti; Caterina F. Ramogida

doi:10.1039/d6qi00525j

January 1, 2026Inorganic Chemistry Frontiers

A Hybrid Pyridine-Thioether Macrocycle to Chelate Theranostic Copper and Silver Radioisotopes

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Key Points

To develop a macrocycle that effectively chelates theranostic copper and silver radioisotopes for cancer applications.
Synthesize a pyridine-thioether macrocycle.
Test the chelation efficacy with copper and silver isotopes.
Evaluate potential for cancer theranostics.
The macrocycle exhibits strong binding with both copper and silver radiometals.
Demonstrated potential for simultaneous diagnostic and therapeutic applications.
Improves the feasibility of clinical translation for cancer therapies.

Implication

A hybrid macrocycle chelates copper and silver radioisotopes for cancer diagnosis and treatment, suggesting improved clinical use.

Abstract

Coinage radiometals such as 64/67Cu and 103/111Ag offer unique opportunities for cancer theranostics, providing matched diagnostic and therapeutic radionuclides within the same chemical family. However, their clinical translation is limited...

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Cite This Study

Tosato et al. (2026) studied this question.

synapsesocial.com/papers/69eb0ac4553a5433e34b4c54 https://doi.org/10.1039/d6qi00525j

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A Hybrid Pyridine-Thioether Macrocycle to Chelate Theranostic Copper and Silver Radioisotopes

Key Points

Implication

Abstract

Discussion

Cite This Study

A Hybrid Pyridine-Thioether Macrocycle to Chelate Theranostic Copper and Silver Radioisotopes

Key Points

Implication

Abstract

Discussion

Cite This Study

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