Bifunctional sulfur-rich macrocyclic chelators and their immunoconjugates for the targeted delivery of theranostic mercury-197

Parmissa Randhawa; Misaki Kondo; A. P. Chu; Cristina Rodríguez‐Rodríguez; Zhongli Cai; Conrad Chen; Yumeela Ganga-Sah; Shaohuang Chen; Neil Weatherall; Patrick Davey; Helen Merkens; Raymond M. Reilly; Valery Radchenko; Caterina F. Ramogida

doi:10.1039/d5pm00222b

January 1, 2025RSC PharmaceuticsOpen Access

Bifunctional sulfur-rich macrocyclic chelators and their immunoconjugates for the targeted delivery of theranostic mercury-197

View Full Paper

Ask AI

Bookmark

Share

Key Points

The study demonstrates effective delivery of theranostic mercury-197 using novel bifunctional chelators, paving the way for advanced cancer treatments.
Targeted delivery using immunoconjugates could significantly enhance the efficacy of treatments, especially in personalized medicine.
These sulfur-rich macrocyclic chelators exhibit optimal properties needed for nuclear medicine applications, which may transform treatment paradigms.
The findings suggest that employing chemically matched theranostic radiometals like mercury-197 can improve treatment outcomes in advanced cancers.

Implication

Novel chelators deliver theranostic mercury-197 effectively in nuclear medicine, highlighting personalized approaches.

Abstract

The use of chemically matched theranostic radiometals in nuclear medicine presents a paradigm shift in personalized medicine with immense potential to treat advanced cancers. The nuclear isomers, possess optimal physical...

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Randhawa et al. (2025) studied this question.

synapsesocial.com/papers/68e8439a9989581a2fd4e08a https://doi.org/10.1039/d5pm00222b

View Full Paper

Ask AI

Bookmark

Share

Bifunctional sulfur-rich macrocyclic chelators and their immunoconjugates for the targeted delivery of theranostic mercury-197

Key Points

Implication

Abstract

Discussion

Cite This Study

Bifunctional sulfur-rich macrocyclic chelators and their immunoconjugates for the targeted delivery of theranostic mercury-197

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading