Increased muscle mass (ALM/BMI) is associated with reduced migraine risk, an effect partially mediated by attenuating systemic inflammation (P=0.045).
Cross-Sectional (n=10,400)
Does increased muscle mass reduce migraine prevalence?
Increased muscle mass is associated with a lower prevalence of migraines, an effect that may be partially mediated by reduced systemic inflammation.
p-value: p=0.045
Purpose: The relationship between adipose-muscle distribution and its effect on migraine remains unclear. This study examines the association between muscle mass and migraine prevalence and evaluates potential mediation by systemic inflammatory biomarkers. Methods: Using a cross-sectional design, we analyzed data from 10,400 participants in the National Health and Nutrition Examination Survey (NHANES) (1999-2004). The association between appendicular lean mass normalized to body mass index (ALM/BMI) and migraine prevalence was evaluated through weighted logistic regression and subgroup analyses. Mediation analyses were conducted to examine the potential mediating roles of inflammatory markers, including C-reactive protein (CRP), white blood cell count (WBC), and neutrophils, in the relationship between ALM/BMI and migraine prevalence. Genetic causality was investigated via two-sample Mendelian randomization (MR) using genome-wide association study (GWAS) data. Results: = 0.045). Conclusion: Increased muscle mass is associated with reduced migraine risk, partially mediated by attenuating systemic inflammation. These findings provide us with an approach of health management to prevent migraines.
Jia et al. (Thu,) conducted a cross-sectional in Migraine (n=10,400). Appendicular lean mass normalized to body mass index (ALM/BMI) was evaluated on Migraine prevalence (p=0.045). Increased muscle mass (ALM/BMI) is associated with reduced migraine risk, an effect partially mediated by attenuating systemic inflammation (P=0.045).
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