February 14, 2015Open Access

Impact of an endurance training program on exercise-induced cardiac biomarker release

ALAlejandro Legaz‐ArreseUniversidad de Zaragoza ILIsaac López‐LavalUniversitat de Lleida KGKeith GeorgeLiverpool John Moores University

Structured PICO

Does a 14-week endurance training program alter the exercise-induced release of hs-cTnT and NT-proBNP in untrained healthy adults?

Population

58 untrained participants (men and women between 18 and 45 years of age). Exclusions: significant personal or early family history of cardiovascular disease, abnormal ECG at baseline, or already pursuing vigorous physical activity.

Intervention

Supervised endurance running program for 14 weeks (3-4 days/week, 120-240 min/week, 65-85% of maximum heart rate).

Comparator

Control group instructed not to change their habits regarding physical activities.

Outcome

Exercise-induced release of high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) assessed before and 5 min, 1 h, 3 h, 6 h, 12 h, and 24 h after a 60-min maximal running test.surrogate

A 14-week endurance training program increases baseline and exercise-induced hs-cTnT release but does not affect NT-proBNP, suggesting hs-cTnT elevation is a physiological adaptation to training rather than purely pathological.

Abstract

We evaluated the influence of a 14-wk endurance running program on the exercise-induced release of high-sensitivity cardiac troponin T (hs-cTnT) and NH2-terminal pro-brain natriuretic peptide (NT-proBNP). Fifty-eight untrained participants were randomized to supervised endurance exercise (14 wk, 3-4 days/wk, 120-240 min/wk, 65-85% of maximum heart rate) or a control group. At baseline and after the training program, hs-cTnT and NT-proBNP were assessed before and 5 min, 1 h, 3 h, 6 h, 12 h, and 24 h after a 60-min maximal running test. Before training, hs-cTnT was significantly elevated in both groups with acute exercise (P < 0.0001) with no between-group differences. There was considerable heterogeneity in peak hs-cTnT concentration with the upper reference limit exceeded in 71% of the exercise tests. After training, both baseline and postexercise hs-cTnT were significantly higher compared with pretraining and the response of the control group (P = 0.008). Acute exercise led to a small but significant increase in NT-proBNP, but this was not mediated by training (P = 0.121). In summary, a controlled endurance training intervention resulted in higher pre- and postexercise values of hs-cTnT with no changes in NT-proBNP.

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