February 14, 2015AJP Heart and Circulatory PhysiologyOpen Access

Impact of an endurance training program on exercise-induced cardiac biomarker release

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Why the study?

Does a 14-week endurance training program alter the exercise-induced release of hs-cTnT and NT-proBNP in untrained healthy adults?

Population

58 untrained participants. Exclusions: significant personal or early family history of cardiovascular…

Comparison

Supervised endurance running program for 14 weeks. vs Control group instructed not to change their…

Design

RCT, Computer-generated randomization list, Examiners blinded to group…

Follow-up

14 weeks

Authors

ALAlejandro Legaz‐ArreseUniversidad de Zaragoza ILIsaac López‐LavalUniversitat de Lleida KGKeith GeorgeLiverpool John Moores University

Discussion

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Implication

hs-cTnT rises after endurance training may reflect adaptation; challenges pathological interpretation and extends RCT biomarker data in healthy adults.

Structured PICO

Does a 14-week endurance training program alter the exercise-induced release of hs-cTnT and NT-proBNP in untrained healthy adults?

Population

58 untrained participants (men and women between 18 and 45 years of age). Exclusions: significant personal or early family history of cardiovascular disease, abnormal ECG at baseline, or already pursuing vigorous physical activity.

Intervention

Supervised endurance running program for 14 weeks (3-4 days/week, 120-240 min/week, 65-85% of maximum heart rate).

Comparator

Control group instructed not to change their habits regarding physical activities.

Outcome

Exercise-induced release of high-sensitivity cardiac troponin T (hs-cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) assessed before and 5 min, 1 h, 3 h, 6 h, 12 h, and 24 h after a 60-min maximal running test.surrogate

A 14-week endurance training program increases baseline and exercise-induced hs-cTnT release but does not affect NT-proBNP, suggesting hs-cTnT elevation is a physiological adaptation to training rather than purely pathological.

Limitations

Limited to assessing the response after an effort of relatively short duration (60 min), limiting extrapolation to elite athletes or longer events
Small sample size of female athletes
Did not address whether the phase of the menstrual cycle could mediate biomarker release

Cite This Study

Legaz‐Arrese et al. (2015) studied this question.

synapsesocial.com/papers/6a0908a1a2bc65e38873bde6 https://doi.org/10.1152/ajpheart.00914.2014

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Implication

hs-cTnT rises after endurance training may reflect adaptation; challenges pathological interpretation and extends RCT biomarker data in healthy adults.

Impact of an endurance training program on exercise-induced cardiac biomarker release

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Impact of an endurance training program on exercise-induced cardiac biomarker release

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

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Also Consider