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November 17, 2009Scandinavian Journal of Medicine and Science in Sports

The impact of exercise duration and intensity on the release of cardiac biomarkers

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Why the study?

Does exercise duration and intensity influence the release of cardiac biomarkers (NT-proBNP and cTnI) in endurance runners?

Population

21 runners scheduled to participate in the 2008 Zaragoza marathon race, mean age 38 and 38.5.

Comparison

Running for 45, 90, and 180 minutes at 85% and… vs Within-subject comparison across different…

Design

RCT, randomized order

Follow-up

3 hours post-exercise

Authors

ESEnrique Serrano-OstárizJTJosé Luis Terreros-BlancoALAlejandro Legaz‐Arrese

Discussion

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Overview

Interpret post-exercise NT-proBNP and cTnI in runners by duration and intensity; extends RCT evidence on differential biomarker responses.

Structured PICO

Does exercise duration and intensity influence the release of cardiac biomarkers (NT-proBNP and cTnI) in endurance runners?

P
Population
21 runners (19 males, 2 females) scheduled to participate in the 2008 Zaragoza marathon race, mean age 38 (males) and 38.5 (females).
I
Intervention
Running for 45, 90, and 180 minutes at 85% and 95% of individual anaerobic threshold (IAT) on 6 different days in randomized order.
C
Comparator
Within-subject comparison across different exercise durations (45, 90, 180 min) and intensities (85% vs 95% IAT).
O
Outcome
Peak post-exercise concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI) measured at 30 min and 3 h post-exercise.surrogate

Exercise duration mediates the release of both NT-proBNP and cTnI, while exercise intensity primarily influences cTnI release in endurance runners.

Limitations

  • Only two female runners recruited, limiting gender comparisons
  • Moderate exercise volume may underpredict competitive running speed
  • Limited blood sampling frequency may have missed true peak concentrations

Cite This Study

Serrano-Ostáriz et al. (2009) studied this question.

synapsesocial.com/papers/6a0908a1a2bc65e38873bdedhttps://doi.org/10.1111/j.1600-0838.2009.01042.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exercise-Induced Cardiac Troponin T Release2007 · 238 citations
  2. 2The Influence of Exercise Upon Cardiac Biomarkers: A Practical Guide for Clinicians and Scientists2007 · 47 citations
  3. 3Post-Race Kinetics of Cardiac Troponin T and I and N-Terminal Pro-Brain Natriuretic Peptide in Marathon Runners2003 · 98 citations
  4. 4Raised troponin T and echocardiographic abnormalities after prolonged strenuous exercise—the Australian Ironman Triathlon2006 · 80 citations
  5. 5Biochemical and functional abnormalities of left and right ventricular function after ultra-endurance exercise2007 · 259 citations