What does this research mean for the field?

The previously published findings regarding the role of miR-495 in inhibiting melanoma cell proliferation, migration, and invasion via PBX3 are invalid due to confirmed image manipulation. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim was to explore how miR-495 affects melanoma cell behaviors like proliferation and invasion through PBX3 inhibition.

May 18, 2026Open Access

miR-495 Inhibits Proliferation, Migration, and Invasion and Induces Apoptosis via Inhibiting PBX3 in Melanoma Cells Retraction

Key Points

The aim was to explore how miR-495 affects melanoma cell behaviors like proliferation and invasion through PBX3 inhibition.
Investigation revealed image panel similarities in Figure 2D.
Differences in treatment conditions were scrutinized by the Journal and Publisher.
Retraction addresses concerns about the validity of claims made regarding miR-495's effects.
No confirmed effects on melanoma cells due to image integrity issues.

Abstract

Further investigation conducted by the Journal and Publisher confirmed unusual similarities present in the image panels representative of different treatment conditions in Figure 2D.

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Cite This Study

Chen et al. (Fri,) studied this question.

synapsesocial.com/papers/6a0aad145ba8ef6d83b70941 https://doi.org/https://doi.org/10.2147/ott.s624309

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