Whole-genome sequence of a varicella-zoster strain from an immunocompetent pediatric patient with severe herpes zoster

Key Points

• This research aims to provide a complete genome sequence analysis of a varicella-zoster strain isolated from a pediatric patient with severe herpes zoster.
• Isolated varicella-zoster virus strain from a 3-year-old immunocompetent patient.
• Characterized the genome, focusing on specific genetic markers like ORF62 and ORF0.
• Noted genetic variations, particularly the methionine to valine substitution in ORF58.
• The strain exhibits an ORF62 genotype characteristic of vOka.
• It contains a wild-type ORF0 gene.
• Identified a novel methionine to valine substitution in ORF58.