What does this research mean for the field?

The CGI strain of varicella-zoster virus, isolated from an immunocompetent pediatric patient with severe herpes zoster, possesses an ORF62 genotype characteristic of vOka, a wild-type ORF0 gene, and a novel methionine to valine substitution in ORF58. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This research aims to provide a complete genome sequence analysis of a varicella-zoster strain isolated from a pediatric patient with severe herpes zoster.

May 20, 2026Microbiology Resource AnnouncementsOpen Access

Whole-genome sequence of a varicella-zoster strain from an immunocompetent pediatric patient with severe herpes zoster

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This research aims to provide a complete genome sequence analysis of a varicella-zoster strain isolated from a pediatric patient with severe herpes zoster.
Isolated varicella-zoster virus strain from a 3-year-old immunocompetent patient.
Characterized the genome, focusing on specific genetic markers like ORF62 and ORF0.
Noted genetic variations, particularly the methionine to valine substitution in ORF58.
The strain exhibits an ORF62 genotype characteristic of vOka.
It contains a wild-type ORF0 gene.
Identified a novel methionine to valine substitution in ORF58.

Implication

Genomic analysis reveals a unique varicella-zoster strain from a child with severe herpes zoster, suggesting genetic insights into VZV pathology.

Abstract

We report the complete genome sequence of CGI, a strain of varicella-zoster virus (VZV) isolated from a 3-year-old immunocompetent patient with severe herpes zoster. The isolated strain exhibits an ORF62 genotype characteristic of vOka, in addition to a wild-type ORF0 gene and a novel methionine to valine substitution in ORF58.

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Cite This Study

Ortigas-Vásquez et al. (2026) studied this question.

synapsesocial.com/papers/6a0d50dcf03e14405aa9d07e https://doi.org/10.1128/mra.01123-25

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Implication

Genomic analysis reveals a unique varicella-zoster strain from a child with severe herpes zoster, suggesting genetic insights into VZV pathology.

Whole-genome sequence of a varicella-zoster strain from an immunocompetent pediatric patient with severe herpes zoster

Key Points

Implication

Abstract

Discussion

Cite This Study

Whole-genome sequence of a varicella-zoster strain from an immunocompetent pediatric patient with severe herpes zoster

Key Points

Implication

Abstract

Discussion

Cite This Study

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