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Introduction Artificial intelligence (AI) adoption in predictive healthcare risk analytics can transform clinical decision-making and resource management; however, its implementation is limited by various socio-technical challenges. Methods This study aims to identify and prioritize the key barriers influencing AI adoption using an integrated Decision-Making Trial and Evaluation Laboratory (DEMATEL) and Analytic Hierarchy Process (AHP) model. Based on a thorough literature review and expert validation, fifteen challenges were identified and categorized into five dimensions: technological, data-related, organizational, human/social, and ethical-regulatory. The DEMATEL method was used to analyse causal relationships among the challenges, while AHP was employed to determine their relative importance through hierarchical weighting. Results The results indicate that the most influential structural drivers affecting adoption include data privacy and protection, data quality and completeness, lack of AI governance, and system interoperability, while leadership and strategic alignment emerge as critical organizational enablers. Data-related and governance-oriented challenges emerged as primary causal factors, whereas human-centred and ethical concerns predominantly appeared as dependent outcomes. Discussion The study concludes that successful adoption of AI in predictive healthcare analytics requires strong leadership support, robust data governance systems, and transparent and interoperable technologies, and provides a structured roadmap for healthcare organizations to achieve scalable and reliable predictive analytics implementation.
Venugopal et al. (Wed,) studied this question.