Inherited and acquired thrombophilias are associated with an increased risk of venous thrombo-embolism, pregnancy loss, and adverse obstetric outcomes, though optimal management remains unclear.
However, the mechanisms by which adverse pregnancy outcomes are influenced by the presence of a thrombophilia have not been fully elucidated and are varied and obscure. There is further emerging evidence that the adverse obstetric outcomes may not be solely secondary to a thrombotic state, but that other pathogenetic mechanisms may aggravate the existing hypercoagulable state.
Feroza Dawood (Tue,) conducted a review in Thrombophilia in pregnancy. Inherited and acquired thrombophilias are associated with an increased risk of venous thrombo-embolism, pregnancy loss, and adverse obstetric outcomes, though optimal management remains unclear.