Key result
Inherited and acquired thrombophilias are associated with an increased risk of venous thrombo-embolism, pregnancy loss, and adverse obstetric outcomes, though optimal management remains unclear.
This review highlights the association between various thrombophilias and adverse pregnancy outcomes, emphasizing the need for large randomized trials to clarify optimal management.
Thrombophilias may raise VTE and obstetric risks; leaves optimal management unresolved without RCTs.
However, the mechanisms by which adverse pregnancy outcomes are influenced by the presence of a thrombophilia have not been fully elucidated and are varied and obscure. There is further emerging evidence that the adverse obstetric outcomes may not be solely secondary to a thrombotic state, but that other pathogenetic mechanisms may aggravate the existing hypercoagulable state.
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Feroza Dawood (2013) conducted a review in Thrombophilia in pregnancy. Inherited and acquired thrombophilias are associated with an increased risk of venous thrombo-embolism, pregnancy loss, and adverse obstetric outcomes, though optimal management remains unclear.
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