Key result
Thrombophilia significantly increases the risk of venous thromboembolism during pregnancy, necessitating individualized prophylactic or therapeutic anticoagulation based on risk stratification.
Why the study?
The etiopathogenesis of obstetric complications in thrombophilia remains unclear, contributing to therapy failure and leaving open questions regarding the role of anticoagulants in preventing pregnancy loss.
Does anticoagulation therapy and screening improve pregnancy outcomes in pregnant women with thrombophilia?
Does anticoagulation therapy and screening improve pregnancy outcomes in pregnant women with thrombophilia?
This review discusses the justification for prescribing anticoagulants and evaluating their effect within thrombophilia therapeutic strategies during pregnancy.
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Insufficient evidence guides anticoagulation in thrombophilia pregnancies; leaves open need for RCTs before practice change.
Lončar et al. (2022) conducted a review in Thrombophilia in pregnancy. Anticoagulation therapy (LMWH, UFH) was evaluated. Thrombophilia significantly increases the risk of venous thromboembolism during pregnancy, necessitating individualized prophylactic or therapeutic anticoagulation based on risk stratification.
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