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August 26, 2009Pacing and Clinical ElectrophysiologyOpen Access

Cryoablation at Growing Myocardium: No Evidence of Coronary Artery Obstruction or Intimal Plaque Formation Early and Late after Energy Application

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Why the study?

Does cryoenergy ablation cause coronary artery obstruction or intimal plaque formation in growing myocardium?

Population

10 piglets (age: 6 weeks, body weight: 14-18 kg)

Design

Preclinical

Follow-up

up to 6 months

Authors

TKThomas KriebelHHHans‐Peter HermannHSHeike Schneider

Discussion

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Overview

Supports further exploration of cryoenergy near coronaries in pediatric models; hypothesis-generating and should not yet change practice.

Structured PICO

Does cryoenergy ablation cause coronary artery obstruction or intimal plaque formation in growing myocardium?

P
Population
10 piglets (age: 6 weeks, body weight: 14-18 kg)
I
Intervention
Cryoenergy ablation (-75 degrees C for 4 minutes using a 7-F catheter with a 6-mm-tip electrode) at the atrial aspect of the tricuspid valve annulus and lateral/posterior atrial and ventricular aspect of the mitral valve annulus
O
Outcome
Coronary artery obstruction or intimal plaque formation assessed by coronary angiography, intracoronary ultrasound, and histological examinationssafety

Cryoablation appears safe for growing myocardium in a pediatric preclinical model, showing no evidence of subsequent coronary artery obstruction or intimal plaque formation.

Cite This Study

Kriebel et al. (2009) studied this question.

synapsesocial.com/papers/6a1b83fb0ac30a8853919b37https://doi.org/10.1111/j.1540-8159.2009.02465.x
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