The Genetics of Hypertrophic Cardiomyopathy

Editorials1 October 1986The Genetics of Hypertrophic CardiomyopathyBARRY J. MARON, M.D., JOHN J. MULVIHILL, M.D.BARRY J. MARON, M.D., JOHN J. MULVIHILL, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-105-4-610 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHypertrophic cardiomyopathy is unusual among primary cardiac diseases in that it frequently shows a familial pattern of occurrence (1-11). That hypertrophic cardiomyopathy could be genetically transmitted was noted by Teare (12) in his initial description of the disease in 1958. This observation was followed by several early reports of single pedigrees in which clinically overt hypertrophic cardiomyopathy was identified in subsequent generations in a pattern consistent with autosomal dominant inheritance (13-23). Other clinical studies in the 1960s showed hypertrophic cardiomyopathy to be familial in about one third of cases (1-3), whereas the remaining two thirds appeared to be sporadic—that is,...References1. BRAUNWALDLAMBREWROCKOFFROSSMORROW ECSJA. Idiopathic hypertrophic subaortic stenosis: I. A description of the disease based upon an analysis of 64 patients. Circulation. 1964;30(suppl IV):3-119. Google Scholar2. FRANKBRAUNWALD SE. Idiopathic hypertrophic subaortic stenosis: clinical analysis of 126 patients with emphasis on the natural history. Circulation. 1968;37:759-88. CrossrefMedlineGoogle Scholar3. EMANUELWITHERSO'BRIEN RRK. Dominant and recessive modes of inheritance in idiopathic cardiomyopathy. Lancet. 1971;2:1065-7. CrossrefMedlineGoogle Scholar4. CLARKHENRYEPSTEIN CWS. Familial prevalence and genetic transmission of idiopathic hypertrophic subaortic stenosis. N Engl J Med. 1973;289:709-14. CrossrefMedlineGoogle Scholar5. VAN DORPTEN CATEVLETTERDOHMENROELANDT WFWHJ. 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Author, Article, and Disclosure InformationAffiliations: National Cancer Institute Bethesda, Maryland PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByEvaluation of myocardial perfusion and function by gated single-photon emission computed tomography technetium-99m methoxyisobutylisonitrile in children and adolescents with severe congenital heart diseaseHerzClinical profile and prognosis of hypertrophic cardiomyopathy when first diagnosed in infancy as opposed to childhoodCardiomegaly in a young infantCreatine PhosphateHereditary dilated cardiomyopathyDYSPNEA DURING PREGNANCYPulmonary veno-occlusive disease associated with hypertrophic cardiomyopathyCardiac Issues in the Pediatric Emergency RoomIdiopathic Hypertrophic Cardiomyopathy in Identical TwinsPathology of cardiomyopathies in childhoodMolecular Insights into Hypertrophic CardiomyopathyEvidence of genetic heterogeneity in five kindreds with familial hypertrophic cardiomyopathy.Myocardial DisordersLocalization of gene for familial hypertrophic cardiomyopathy to chromosome 14q1 in a diverse US population.Pathogenesis of hypertrophic cardiomyopathy: another viewpointFatal hypertrophic cardiomyopathy in an infant of a diabetic motherCytogenetic Studies in Familial Hypertrophic Cardiomyopathy: Identification of a Fragile Site on Human Chromosome 16Hypertrophic cardiomyopathy in identical twins.The significance of increased left ventricular outflow tract velocities in the elderly measured by continuous wave DopplerThe challenge of cardiomyopathyRegional myocardial blood flow and metabolism at rest in mildly symptomatic patients with hypertrophic cardiomyopathyElderly patients with hypertrophic cardiomyopathy: A subset with distinctive left ventricular morphology and progressive clinical course late in lifeHypertrophic Cardiomyopathy 1 October 1986Volume 105, Issue 4Page: 610-613KeywordsCardiomyopathiesGenetic diseasesHeart diseases Issue Published: 1 October 1986 PDF DownloadLoading ...