Surgical production of complete heart block in dogs acutely reduced cardiac output, coronary flow, and mean arterial pressure, with myocardial hypertrophy developing between 2 and 18 days.
A study has been conducted immediately and up to 18 days after the surgical production of complete heart block in dogs. Immediately after surgery cardiac output, coronary flow, and mean arterial pressure were reduced in rough proportion to the degree of bradycardia. In time, these measures began to return toward preoperative levels. Paralleling the diminished left ventricular work was a diminished left ventricular oxygen consumption with little consequent change in myocardial efficiency. Small rises were detected in central venous pressure. At autopsy, the only unequivocal abnormality was myocardial hypertrophy which became measurable between 2 and 18 days after operation.
Starzl et al. (Fri,) conducted a other in Acute complete heart block. Surgical production of complete heart block vs. Preoperative baseline was evaluated on Hemodynamic parameters and myocardial changes. Surgical production of complete heart block in dogs acutely reduced cardiac output, coronary flow, and mean arterial pressure, with myocardial hypertrophy developing between 2 and 18 days.
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