Can we trust non-polio enterovirus sero-surveillance? Evaluation of cross-neutralisation between enteroviruses

Key Points

• This research aims to assess the reliability of non-polio enterovirus sero-surveillance by evaluating cross-neutralisation among different enteroviruses.
• Conducted sero-surveillance to measure antibody responses against non-polio enteroviruses.
• Analyzed cross-neutralisation reactions in vitro between various enterovirus serotypes.
• Evaluated immune responses to identify potential overlaps in neutralisation.
• Identified significant cross-neutralisation between several enterovirus serotypes, particularly in responses to serotype-specific antibodies.
• Demonstrated variability in immune responses, indicating potential challenges for interpreting sero-surveillance data.