What is the clinical evidence from this study?

Study design: Other. Population: Healthy older adults (n=11). Intervention: High-intensity exercise (75%-80% HRmax) vs. Low-intensity exercise (50%-55% HRmax). Primary outcome: Brachial artery flow-mediated dilation (FMD) 10 min postexercise (p=<0.01).

August 16, 2017Open Access

High-Intensity Exercise Enhances Conduit Artery Vascular Function in Older Adults

Q: What are the key findings of this study?

High-intensity exercise acutely enhanced brachial artery flow-mediated dilation 10 minutes postexercise (from 4.8% to 9.1%, P<0.01), whereas low-intensity exercise did not.

EIErika IwamotoSapporo Medical University JBJoshua M. BockNew York City Health and Hospitals Corporation DCDarren P. CaseyUniversity of Iowa

Key Result

High-intensity exercise acutely enhanced brachial artery flow-mediated dilation 10 minutes postexercise (from 4.8% to 9.1%, P<0.01), whereas low-intensity exercise did not.

Structured PICO

Does an acute bout of high-intensity exercise improve conduit and resistance artery function compared to low-intensity exercise in healthy older adults?

Population

11 healthy older adults (mean age 66 years, 54.5% female) who completed 30 minutes of low- and high-intensity recumbent cycling on separate visits.

Intervention

Acute bout of high-intensity exercise (30 min of recumbent cycling at 75%-80% of age-predicted HRmax).

Comparator

Acute bout of low-intensity exercise (30 min of recumbent cycling at 50%-55% of age-predicted HRmax) on a separate study visit.

Outcome

Brachial artery flow-mediated dilation (FMD) and reactive hyperemia (peak and total blood flow) measured by Doppler ultrasound at 10 min and 1 h postexercise.surrogate

High-intensity exercise acutely improves conduit artery function in healthy older adults, whereas resistance artery function improves regardless of exercise intensity.

Main Result

Absolute Event Rate: 9.1% vs 6.2%

p-value: p=<0.01

Abstract

PURPOSE: Modulation of vascular function follows an exercise intensity-dependent pattern in young adults. This study aimed to investigate the potential intensity-dependent effects of an acute bout of exercise on conduit and resistance artery function in healthy older adults. METHODS: Eleven healthy older adults (five males/six females, 66 ± 1 yr) completed 30 min of recumbent cycling at 50%-55% (low intensity) and 75%-80% (high intensity) of their age-predicted HRmax on two separate study visits. Doppler ultrasound measures of brachial artery flow-mediated dilation (FMD) and reactive hyperemia were taken at baseline, 10 min postexercise, and 1 h postexercise. In addition, cardiovascular hemodynamics and brachial shear rate were measured every 5 min during exercise. RESULTS: Brachial artery FMD was enhanced 10 min after high-intensity exercise (4.8% ± 0.2% to 9.1% ± 0.3%, P 0.05). CONCLUSION: Our data indicate that high-intensity exercise acutely enhances conduit artery function in healthy older adults. In addition, an acute bout of exercise enhances resistance artery function independent of intensity.

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