Persistent atrial fibrillation was associated with significantly higher left atrial glucose uptake compared to controls, which decreased significantly 3 months after return to sinus rhythm.
Observational (n=36)
Does restoration of sinus rhythm by catheter ablation alter left atrial glucose metabolism in patients with persistent atrial fibrillation?
36 patients with persistent atrial fibrillation undergoing catheter ablation evaluated before and 3 months after return to sinus rhythm, compared against healthy controls.
Catheter ablation to restore sinus rhythm, with left atrial glucose metabolism evaluated by nicotinic acid derivative stimulated 18F-FDG-PET before and 3 months after return to sinus rhythm
Healthy controls and intra-patient baseline (persistent AF state)
Left atrial glucose metabolism (total left atrial and left atrial appendage FDG uptake)surrogate
Persistent atrial fibrillation is associated with increased left atrial glucose metabolism that decreases after restoration of sinus rhythm, suggesting metabolic wasting plays a role in AF pathophysiology.
The role of atrial metabolism alterations for initiation and atrial fibrillation (AF) persistence remains poorly understood. Therefore, we evaluated left atrial glucose metabolism by nicotinic acid derivative stimulated 18-fluorodeoxyglucose positron emission tomography in 36 patients with persistent AF undergoing catheter ablation before and 3 months after return to sinus rhythm and compared values against healthy controls. Under identical hemodynamics and metabolic conditions, and although left ventricular FDG uptake remained unchanged, patients in persistent AF presented significantly higher total left atrial and left atrial appendage uptake, which decreased significantly after return to sinus rhythm, despite improvement of passive and active atrial contractile function. These findings support a role of altered glucose metabolism and metabolic wasting underlying the pathophysiology of persistent AF.
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Marchandise et al. (Wed,) conducted a observational in Persistent atrial fibrillation (n=36). Persistent atrial fibrillation vs. Healthy controls and return to sinus rhythm was evaluated on Left atrial glucose metabolism (total left atrial and left atrial appendage FDG uptake). Persistent atrial fibrillation was associated with significantly higher left atrial glucose uptake compared to controls, which decreased significantly 3 months after return to sinus rhythm.
synapsesocial.com/papers/6a20e24134bef10fdaeb197c — DOI: https://doi.org/10.1016/j.jacbts.2023.11.001
Sébastien Marchandise
Cliniques Universitaires Saint-Luc
Véronique Roelants
Cliniques Universitaires Saint-Luc
Tristan Raoult
Cliniques Universitaires Saint-Luc
JACC Basic to Translational Science
UCLouvain
Cliniques Universitaires Saint-Luc
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