Design, synthesis, and mechanistic evaluation of novel pyrazole/thiazole chalcone hybrids as dual tubulin polymerization and COX-2 inhibitors with potent antiproliferative activity | Synapse
June 4, 2026Open Access
Design, synthesis, and mechanistic evaluation of novel pyrazole/thiazole chalcone hybrids as dual tubulin polymerization and COX-2 inhibitors with potent antiproliferative activity
Key Points
This research aims to design and evaluate new pyrazole/thiazole chalcone hybrids as inhibitors of tubulin and COX-2 for cancer treatment.
Designed and synthesized a series of chalcone hybrids (9a–o)
Evaluated inhibitors' potency against tubulin polymerization and COX-2 activity
Assessed antiproliferative effects in cancer cells.
Identified novel hybrids with significant dual inhibition of tubulin polymerization and COX-2
Demonstrated potent antiproliferative activity compared to existing treatments.
Abstract
A novel series of pyrazole/thiazole chalcone hybrids (9a–o) was designed, synthesized, and evaluated as dual tubulin/COX-2 inhibitors with anticancer activity.