Design, synthesis, and mechanistic evaluation of novel pyrazole/thiazole chalcone hybrids as dual tubulin polymerization and COX-2 inhibitors with potent antiproliferative activity

Basima A. A. SALEEM; Ashraf A. Qurtam; Abdelrahman R. Shalabi; Mohammed Al-zharani; Kasim Sakran Abass; Stefan Bräse; Ghallab Alotaibi; Abdullah Alkhammash

doi:10.1039/d6ra03557d

January 1, 2026RSC AdvancesOpen Access

Design, synthesis, and mechanistic evaluation of novel pyrazole/thiazole chalcone hybrids as dual tubulin polymerization and COX-2 inhibitors with potent antiproliferative activity

View Full Paper

Ask AI

Bookmark

Share

Key Points

This research aims to design and evaluate new pyrazole/thiazole chalcone hybrids as inhibitors of tubulin and COX-2 for cancer treatment.
Designed and synthesized a series of chalcone hybrids (9a–o)
Evaluated inhibitors' potency against tubulin polymerization and COX-2 activity
Assessed antiproliferative effects in cancer cells.
Identified novel hybrids with significant dual inhibition of tubulin polymerization and COX-2
Demonstrated potent antiproliferative activity compared to existing treatments.

Implication

Evaluates new chalcone hybrids for anticancer activity, suggesting potential therapies.

Abstract

A novel series of pyrazole/thiazole chalcone hybrids (9a–o) was designed, synthesized, and evaluated as dual tubulin/COX-2 inhibitors with anticancer activity.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

SALEEM et al. (2026) studied this question.

synapsesocial.com/papers/6a2116fad499ed480b16fe65 https://doi.org/10.1039/d6ra03557d

View Full Paper

Ask AI

Bookmark

Share

Design, synthesis, and mechanistic evaluation of novel pyrazole/thiazole chalcone hybrids as dual tubulin polymerization and COX-2 inhibitors with potent antiproliferative activity

Key Points

Implication

Abstract

Discussion

Cite This Study

Design, synthesis, and mechanistic evaluation of novel pyrazole/thiazole chalcone hybrids as dual tubulin polymerization and COX-2 inhibitors with potent antiproliferative activity

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading