What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Hypertension (n=803). Intervention: Hypertension vs. Normotension. Primary outcome: 24-hour central systolic BP.

January 1, 2015Open Access

Evaluation of 24-Hour Arterial Stiffness Indices and Central Hemodynamics in Healthy Normotensive Subjects versus Treated or Untreated Hypertensive Patients: A Feasibility Study

Key Result

Hypertensive patients had significantly higher 24-hour central systolic BP (119.3 vs 105.6 mmHg) and aortic pulse wave velocity (10.3 vs 10.0 m/sec) than normotensive subjects.

Study Design

Type

Cross-Sectional (n=803)

Structured PICO

Do 24-hour central blood pressure and arterial stiffness indices differ between hypertensive patients and healthy normotensive subjects?

Population

803 participants, comprising 142 healthy normotensive subjects and 661 hypertensive patients, evaluated for 24-hour arterial stiffness and central hemodynamics.

Exposure

Hypertension (treated or untreated)

Comparator

Normotension (healthy volunteers)

Outcome

24-hour central blood pressure and vascular indices (pulse wave velocity, augmentation index, and reflected wave transit time) estimated noninvasively by pulse wave analysis of ambulatory blood pressure recordingssurrogate

Noninvasive 24-hour ambulatory pulse wave analysis can detect significant differences in central hemodynamics and arterial stiffness between hypertensive and normotensive individuals.

Main Result

Absolute Event Rate: 119.3% vs 105.6%

Abstract

Objective. Central blood pressure (BP) and vascular indices estimated noninvasively over the 24 hours were compared between normotensive volunteers and hypertensive patients by a pulse wave analysis of ambulatory blood pressure recordings. Methods. Digitalized waveforms obtained during each brachial oscillometric BP measurement were stored in the device memory and analyzed by the validated Vasotens technology. Averages for the 24 hours and for the awake and asleep subperiods were computed. Results. 142 normotensives and 661 hypertensives were evaluated. 24-hour central BP, pulse wave velocity (PWV), and augmentation index (AI) were significantly higher in the hypertensive group than in the normotensive group (119.3 versus 105.6 mmHg for systolic BP, 75.6 versus 72.3 mmHg for diastolic BP, 10.3 versus 10.0 m/sec for aortic PWV, -9.7 versus -40.7% for peripheral AI, and 24.7 versus 11.0% for aortic AI), whereas reflected wave transit time (RWTT) was significantly lower in hypertensive patients (126.6 versus 139.0 ms). After adjusting for confounding factors a statistically significant between-group difference was still observed for central BP, RWTT, and peripheral AI. All estimates displayed a typical circadian rhythm. Conclusions. Noninvasive assessment of 24-hour arterial stiffness and central hemodynamics in daily life dynamic conditions may help in assessing the arterial function impairment in hypertensive patients.

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Cite This Study

Omboni et al. (Thu,) conducted a cross-sectional in Hypertension (n=803). Hypertension vs. Normotension was evaluated on 24-hour central systolic BP. Hypertensive patients had significantly higher 24-hour central systolic BP (119.3 vs 105.6 mmHg) and aortic pulse wave velocity (10.3 vs 10.0 m/sec) than normotensive subjects.

synapsesocial.com/papers/6a2467cef2726a70c0bf2b0b https://doi.org/https://doi.org/10.1155/2015/601812

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