Treatment with the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro prevented elevated blood pressure and restored systemic pressure to normal in dogs with experimental renovascular hypertension.
Does the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro prevent or reduce elevated blood pressure in a dog model of renovascular hypertension?
The study provides strong evidence that the renin-angiotensin system initiates hypertension in renovascular disease by demonstrating that an ACE-inhibiting nonapeptide prevents and reverses blood pressure elevation.
Constriction of the renal artery and controlled reduction of renal perfusion pressure is followed by a prompt increase in systemic renin activity and a concomitant rise in blood pressure in trained, unanesthetized dogs. The elevated blood pressure induced by the renal artery stenosis can be prevented by prior treatment with the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro, which blocks conversion of angiotensin I to angiotensin II. Further, the nonapeptide can restore systemic pressure to normnal in the early phase of renovascular hypertension. These results offer strong evidence that the renin-angiotensin system is responsible for the initiation of hypertension in the unilaterally nephrectomized dog with renal artery constriction.
Miller et al. (Fri,) conducted a other in Experimental Renovascular Hypertension. Nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro was evaluated on Blood pressure. Treatment with the nonapeptide Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro prevented elevated blood pressure and restored systemic pressure to normal in dogs with experimental renovascular hypertension.