Use of anti-adhesion gel after hysteroscopy for the treatment of female infertility: A systematic review and meta-analysis

This systematic review and meta-analysis assessed the effectiveness of anti-adhesion gels in preventing intrauterine adhesions (IUA) and improving reproductive outcomes following hysteroscopic procedures. Twelve randomized controlled trials involving a total of 1709 patients were included. The results indicated that anti-adhesion gels significantly reduced both the incidence and recurrence of IUA and were associated with a lower American Fertility Society (AFS) score. Furthermore, their use was linked to improved pregnancy and live birth rates. However, no significant effects were found on menstrual improvement or pregnancy loss rates. These findings suggest that anti-adhesion gels may be beneficial in enhancing postoperative reproductive outcomes and reducing adhesion-related complications after hysteroscopy. Further research is needed to clarify the role of anti-adhesion in menstrual recovery and miscarriage prevention.