Figure S2 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

Key Points

• RGN6024 effectively destabilizes tubulin, which is critical for cell division in glioblastoma.
• The treatment shows significant inhibition of tubulin polymerization, indicating a mechanism for action against cancer cells.
• Cellular assays confirmed RGN6024's ability to bind to tubulin, enhancing its anti-cancer properties.
• These findings may lead to new treatment options for glioblastoma, a challenging and aggressive brain tumor.