Table S4 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

Key Points

• MAIN FINDING: RGN6024 effectively functions as a brain-penetrant tubulin destabilizer targeting glioblastoma.
• KEY EVIDENCE: Experiments indicate that the small-molecule RGN6024 reduces βIII-tubulin levels significantly.
• APPROACH: The study utilizes overexpression experiments to analyze the impact of RGN6024 on glioblastoma cells.
• SIGNIFICANCE: This research contributes to potential new therapies for glioblastoma, addressing a challenging cancer type.