Objective: To investigate the impact of residual inflammatory risk (RIR) and leukocytosis on post-stroke cognitive impairment (PSCI) in patients with acute ischemic stroke (AIS). Methods: A retrospective analysis was conducted on 300 AIS patients admitted between January 2022 and December 2025. They were divided into a PSCI group (n=120) and a non-PSCI group (n=180) based on the occurrence of PSCI. Inflammatory markers such as white blood cell count (WBC), high-sensitivity C-reactive protein (hs-CRP), and NLR were measured to evaluate RIR. Multifactor logistic regression analysis was used to assess the relationship between RIR, leukocytosis, and PSCI. Results: The levels of WBC, hs-CRP, and IL-6 were significantly higher in the PSCI group than in the non-PSCI group (P<0.05). Multifactor regression analysis showed that leukocytosis (OR=2.45, 95%CI: 1.62–3.71), RIR (OR=3.12, 95%CI: 1.98–4.92), age ≥65 years (OR=3.113, P=0.001), and NIHSS ≥6 were independent risk factors for PSCI. Among them, hs-CRP had the highest diagnostic value, followed by WBC. Conclusion: Residual inflammatory risk and leukocytosis are closely related to the occurrence of cognitive impairment after acute ischemic stroke and may become predictive indicators and intervention targets for PSCI.
Guo et al. (Wed,) studied this question.
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