Gastrointestinal stromal tumors (GISTs) of the colon are extremely rare and often present diagnostic challenges due to overlapping features with inflammatory or other neoplastic conditions. We report the case of a 43-year-old female initially referred for evaluation of presumed colitis who was found on colonoscopy to have a sigmoid mass. Initial biopsies showed inflammation without malignancy, but subsequent imaging and pathology confirmed a GIST. After multidisciplinary evaluation, she underwent an uncomplicated robotic-assisted partial colectomy. Final pathology confirmed a 2.2 × 1.9 × 0.6 cm low-mitotic index GIST positive for CD117 and DOG-1, with no residual disease. Postoperative recovery was favorable; adjuvant management is ongoing. This case highlights the importance of maintaining a broad differential for colonic masses and demonstrates how early multidisciplinary intervention can guide optimal surgical and oncologic care, even in atypical GIST presentations.
Patel et al. (Thu,) studied this question.
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