What type of study is this?

This is a Cross-Sectional study.

September 5, 2025Open Access

Comparison of Quantitative C-Reactive Protein with Blood Lactate Levels as Septic Markers in Neonatal Sepsis: A Cross-Sectional Study in a Tertiary Care Setting, Rawalpindi

Key Points

Lactate levels were significantly lower in survivors compared to non-survivors, indicating its predictive value for mortality.
The presence of multiple organ dysfunction syndrome was notably higher in non-survivors than in survivors, emphasizing severity.
C-reactive protein and lactate both correlate with increased severity of neonatal sepsis, affecting clinical outcomes.
The analysis included 136 neonates diagnosed with sepsis, enhancing the study's robustness and relevance.

Abstract

Objective: To find the relationship between the quantitative C-reactive protein and lactate as septic markers inneonatal sepsis.Study Design: Cross-sectional study.Place and Duration of Study: This study was conducted at the Neonatal Intensive Care Unit of CombinedMilitary Hospital (CMH), Peshawar, Pakistan from March 2024 to August 2024.Methods: Neonates (age 1 day–28 days) diagnosed with sepsis were enrolled. Patients were categorized intotwo groups: Group I (Survivors) and Group II (Non-survivors). Patient's demographic details, blood cultures,serum C-reactive protein, neutrophil counts, plasma Lactate, and outcome in terms of hospital discharge wereassessed and recorded. Data analysis was done using SPSS version 26.Results: Of the total 136 neonates, there were 76 (55.9%) male and 60 (44.1%) female. The overall mean agewas 14.56±7.82 days. Group I had 92 (67.6%) survivors and Group II had 44 (32.4%) non-survivors. The medianvalue of Lactate (millimole/Liter) and C-reactive protein (milligram/deciliter) was 2.3 (IQR 1.4-5.3) and 2.1 (IQR0.15-8.7), respectively. Survivor group (Group-I) had lower Lactate (1.9 millimole/Liter 1.2–9 than the nonsurvivor group (4.5 millimole/Liter 2.15–7.4), P < 0.05. The prevalence of multiple organ dysfunction wassignificantly higher in Group-II 82 (89.1%) than in Group-I 16 (36.4%). Based on organism causing infectionsamong 136 neonatal sepsis cases, the incidence of Group B Streptococcus, Escherichia coli, Listeriamonocytogenes, Coagulase-Negative Staphylococci, Staphylococcus aureus, Enterococcus species, Klebsiellaspecies, and Pseudomonas aeruginosa was 58 (43%), 32 (24%), 9 (7%), 7 (5%), 4 (3%), 14 (10%), 10 (7%), and 2(1%), respectively.Conclusion: Lactate is superior to C-reactive protein in predicting prognosis and mortality in neonatal sepsis inthe Neonatal intensive care unit. Elevated levels of lactate and C-reactive protein are primarily associated withincreased severity of neonatal sepsis, including the progression to multiple organ dysfunction syndrome(MODS), septic shock, and poor clinical outcomes. How to cite this: Ali F, Aqib AR, Ahmad N, Ibrahim S, Rehman M, Usman A. Comparison of Quantitative C-Reactive Protein with Blood Lactate Levels as Septic Markers in Neonatal Sepsis: A Cross-Sectional Study in a Tertiary Care Setting, Rawalpindi. Life and Science. 2025; 6(3): 310-316. doi: http://doi.org/10.37185/LnS.1.1.740

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Ali et al. (Thu,) studied this question.

synapsesocial.com/papers/68bb3efd2b87ece8dc957c31 https://doi.org/https://doi.org/10.37185/lns.1.1.740

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