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September 5, 2025

Primary Splenic Nodular Lymphocyte Predominant Hodgkin Lymphoma (NLPHL): First Reported Case in a Young Child

Key Points

This case highlights the potential for long-term survival in young patients with primary splenic NLPHL.
The child remained free of disease three years post-splenectomy, despite the usual poor prognosis associated with splenic involvement.
Primary splenic NLPHL is rare, typically presenting as an advanced stage of disease in most cases, but this case defies that notion.
Indolent B-cell lymphoma like NLPHL often has a favorable outcome, challenging the assumptions about splenic involvement.

Abstract

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare subtype of B-cell lymphoma. NLPHL is usually indolent, involves lymph nodes and shows a favorable prognosis with high overall survival. In a minority of cases, patients may present and/or progress to advanced disease with involvement of the spleen, liver, and/or bone marrow. While splenic involvement by NLPHL is usually presumed evidence of advanced disease with poor prognosis, here we report to our knowledge, the first case of primary splenic NLPHL occurring in a child who showed no overt nodal disease and is currently free of disease 3 years post-splenectomy without additional treatment.

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Cite This Study

Vergara et al. (Wed,) studied this question.

synapsesocial.com/papers/68bb420d2b87ece8dc95819d https://doi.org/https://doi.org/10.1177/10935266251368431

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