Supplementary Figure 3 from ERBB2/HER2 Alterations in ctDNA and Metachronous Tissues of Patients with Metastatic Urothelial Cancer

Key Points

• Breakage-fusion-bridge events indicate genomic instability in metastatic urothelial cancer.
• Whole-genome sequencing of circulating tumor DNA revealed the presence of these events.
• Analysis shows the connection between ctDNA and HER2 alterations in patients with advanced cancer.
• Findings emphasize the importance of ctDNA as a potential biomarker for cancer progression.