Background: Atrial fibrillation (AF) significantly raises the risk of ischemic stroke, heart failure, cognitive decline, and cardiovascular death. In view of the substantial economic and healthcare challenges posed by AF, it is crucial to identify risk factors and develop effective prevention strategies. Several studies published in different times showed inconsistent results regarding its relation with dyslipidemia. Aims and Objectives: The aims and objectives were to find out the relationship between different lipid levels total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL), and AF. Materials and Methods: A total of 83 patients attending the department of cardiology with nonvalvular AF were included in the study group. Results: Coronary artery disease (CAD) with AF (28.9%) was the most common diagnosis, followed by heart failure with preserved ejection fraction (HFpEF) with AF (20.5%), lone AF (14.5%), hypertrophic cardiomyopathy (HCM) with AF (14.5%). The mean LDL levels were highest in patients with CAD (115.07±16.3 mg/dL) and HFpEF (113.11±12.99 mg/dL), whereas the mean TC levels were also elevated in these groups. The mean HDL level was lowest among patients with lone AF (29.4±5.6 mg/dL). Conclusion: Elevated LDL and TC levels are more frequently observed in patients with CAD and HFpEF, whereas low HDL levels are linked to lone AF. In patients with cardiomyopathies and lone AF, LDL and TC values are in the lower range supporting the “cholesterol paradox”.
Kumari et al. (Fri,) studied this question.