Microemulgels have emerged as a cutting-edge drug delivery system that synergistically combines the advantages of microemulsions and gels, offering a versatile platform for pharmaceutical and cosmeceutical applications. By leveraging the solubilizing power of microemulsions with the patientfriendly application of gels, microemulgels address several limitations associated with conventional topical and transdermal drug delivery systems. These hybrid systems are particularly advantageous due to their enhanced drug solubility, improved stability, controlled and sustained drug release profiles, and superior patient compliance. Microemulgels provide a non-invasive alternative for systemic drug delivery and are especially suitable for lipophilic drugs that are otherwise poorly absorbed through the skin. Their biphasic structure allows for the incorporation of both hydrophilic and lipophilic therapeutic agents, making them ideal for a wide range of clinical indications. The review delves into novel formulation strategies such as thermosensitive microemulgels, stimuli-responsive systems, and bioadhesive gels, which expand the utility of these systems in both chronic and acute conditions. Characterization methodologies, including rheology, particle size analysis, zeta potential measurements, and in vitro diffusion studies, are discussed to underscore the importance of quality control and performance prediction.
Patidar et al. (Fri,) studied this question.
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