Molecular design of NIR type I phenothiazine-based photosensitizers with aggregation-enhanced ROS generation for effective photodynamic therapy applications | Synapse
September 10, 2025
Molecular design of NIR type I phenothiazine-based photosensitizers with aggregation-enhanced ROS generation for effective photodynamic therapy applications
Key Points
Enhanced ROS generation was achieved through molecular design of phenothiazine-based photosensitizers.
Four new photosensitizers were synthesized by integrating various electron donor groups to optimize performance.
The study focuses on the design principles that improve photodynamic therapy applications using photosensitizers.
Improved understanding of electron donor effects could lead to more effective treatments in photodynamic therapy.
Abstract
In this work, four phenothiazine (PHE)-based PSs (termed PPI1, PPI2, TPI1, and TPI2) were designed and synthesized by integrating various electron donor groups with PHE to regulate their donor structure.