What type of study is this?

This is a Cross-Sectional study.

September 10, 2025Open Access

Exploring Nailfold Videocapillaroscopy in Children with Psoriatic Arthritis: Are There Any Hidden Vascular Signatures?

Key Points

Increased capillary tortuosity and microhemorrhages are notable findings in children with juvenile psoriatic arthritis.
Capillary density did not differ significantly, with correlations seen between disease duration and microvascular changes.
Assessment using nailfold videocapillaroscopy focused on capillary morphology and microhemorrhages in 25 JPsA patients.
These findings prompt further longitudinal studies to verify nailfold videocapillaroscopy's clinical implications in juvenile psoriatic arthritis.

Abstract

Abstract Objectives Juvenile psoriatic arthritis (JPsA), a subtype of juvenile idiopathic arthritis, is a chronic inflammatory disease characterized by joint and skin involvement. Microvascular alterations, including endothelial dysfunction and inflammation, are thought to contribute to its pathophysiology. Nailfold videocapillaroscopy (NVC) is a non-invasive technique for assessing microvascular changes. This study aimed to evaluate NVC findings in children with JPsA compared to healthy controls, investigating its potential diagnostic and monitoring utility. Methods This cross-sectional study included 25 children with JPsA and 33 age- and sex-matched healthy controls. NVC was performed on eight fingers per participant, focusing on capillary density, morphology, and the presence of microhemorrhages. Disease activity was assessed using the Juvenile Arthritis Disease Activity Score-27. Statistical analyses compared capillaroscopic findings between groups and explored correlations with clinical parameters. Results In JPsA patients, tortuous capillaries (84% versus 24%, p 0.001), crossed capillaries (100% versus 63.6%, p = 0.001), and microhemorrhages (28% versus 0%, p = 0.002) were significantly more frequent compared to controls. No specific capillaroscopy pattern was detected in the JPsA cohort. Capillary density and apical loop widths did not differ significantly between groups (p = 0.92 and p = 0.93, respectively). Disease duration negatively correlated with capillary density (r = −0.484, p = 0.014), suggesting progressive microvascular changes over time. Conclusion Nailfold videocapillaroscopy revealed distinct microvascular abnormalities in children with JPsA, including increased tortuosity and microhemorrhages, highlighting its potential as a diagnostic and monitoring tool. Longitudinal studies with larger cohorts are warranted to validate these findings and clarify the prognostic significance of NVC in JPsA.

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Cite This Study

Menentoğlu et al. (Fri,) studied this question.

synapsesocial.com/papers/68c1d97154b1d3bfb60faae6 https://doi.org/https://doi.org/10.1093/mr/roaf079

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