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September 12, 2025Angewandte Chemie International Edition0 citations

Electrochemical Amide Synthesis from Acetonitrile Using Superoxide

Steering Amide Synthesis from Acetonitrile by Electrochemically Derived Active Superoxide

Authors

Tandem electro-thermal catalysis enhances amide yield in acetonitrile, suggesting efficient synthesis methods.

Achieved over 94% selectivity for acetamide using superoxide radicals, enhancing synthesis efficiency.
A total current density of 104 mA cm−2 led to a productivity of 878 µmol cm−2 h−1 in the process.
Mechanistic studies indicate superoxide radicals enable effective C─O coupling at the nitrile group.
This method highlights the potential for developing various amides and advancing organic synthesis.

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Dong et al. (2025) studied this question.

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September 12, 2025Angewandte Chemie International Edition0 citations

Steering Amide Synthesis from Acetonitrile by Electrochemically Derived Active Superoxide

Authors

Tandem electro-thermal catalysis enhances amide yield in acetonitrile, suggesting efficient synthesis methods.

Achieved over 94% selectivity for acetamide using superoxide radicals, enhancing synthesis efficiency.
A total current density of 104 mA cm−2 led to a productivity of 878 µmol cm−2 h−1 in the process.
Mechanistic studies indicate superoxide radicals enable effective C─O coupling at the nitrile group.
This method highlights the potential for developing various amides and advancing organic synthesis.

Ask AI

Helpful

Bookmark

View Full Paper

Dong et al. (2025) studied this question.

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Helpful

Bookmark

View Full Paper