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September 12, 2025Angewandte Chemie International Edition

Steering Amide Synthesis from Acetonitrile by Electrochemically Derived Active Superoxide

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Authors

LDLingyu DongYWYutai WuYWYifan Wang

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Overview

Tandem electro-thermal catalysis enhances amide yield in acetonitrile, suggesting efficient synthesis methods.

Key Points

  • Achieved over 94% selectivity for acetamide using superoxide radicals, enhancing synthesis efficiency.
  • A total current density of 104 mA cm−2 led to a productivity of 878 µmol cm−2 h−1 in the process.
  • Mechanistic studies indicate superoxide radicals enable effective C─O coupling at the nitrile group.
  • This method highlights the potential for developing various amides and advancing organic synthesis.

Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/68d44a4731b076d99fa53d6bhttps://doi.org/10.1002/anie.202513359
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Steering Amide Synthesis from Acetonitrile by Electrochemically Derived Active Superoxide2025
  2. 2Tandem C−N Coupling for Acetamide Synthesis via Paired Electrolysis Using a Bifunctional Catalyst2026
  3. 3Direct electrosynthesis of acetamide from CO2 and nitrate via an atomically engineered dual-site catalyst2026
  4. 4Electrocatalytic Amide Synthesis: Mechanistic Pathways and Selectivity Control in C‐N Coupling2026
  5. 5Selective Deoxygenative Electroreduction of Amides2026 · 3 citations