This research demonstrates a novel electro-thermal catalytic pathway for efficient amide synthesis, highlighting effective superoxide utilization and high selectivity.
Key Points
Over 94% selectivity toward acetamide was achieved through electro-thermal catalysis under ambient conditions.
Using a total current density of 104 mA cm−2, the productivity reached 878 µmol cm−2 h−1, showcasing effective radical formation.
Mechanistic studies indicated superoxide radicals enabled nucleophilic coupling, while methanol prevented over-oxidation to acetate.
The approach may inspire complex organic syntheses, improving atom economy with active oxygen species.