Experimental analysis reveals that astragalus polysaccharide reduces reactive oxygen species in sarcopenic mice, suggesting a mechanism to enhance muscle protein levels.
Key Points
APS improves muscle cell proliferation by activating the AKT-mTOR pathway, reducing oxidative stress.
Animal experiments showed significant decreases in ROS levels and increases in superoxide dismutase 2 gene expression with APS treatment.
The concentration of APS administered was directly related to the improvement in muscle health observed.
Activation of the mTOR pathway in muscle cells indicates a promising therapeutic strategy for treating sarcopenia.