What type of study is this?

This is a Animal Study study (also classified as: Quantitative Study, In Vitro Study).

September 16, 2025Pharmacognosy MagazineOpen Access

Astragalus Polysaccharide Activates the AKT-mTOR Pathway to Reduce ROS and Promote Intramuscular Protein Levels in Sarcopenia Mice

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Authors

JXJingcai XuXi'an University of Science and Technology XZXu Dong ZhangBengbu Medical College KLKai LiZhengzhou University of Light Industry

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Implication

Experimental analysis reveals that astragalus polysaccharide reduces reactive oxygen species in sarcopenic mice, suggesting a mechanism to enhance muscle protein levels.

Key Points

APS improves muscle cell proliferation by activating the AKT-mTOR pathway, reducing oxidative stress.
Animal experiments showed significant decreases in ROS levels and increases in superoxide dismutase 2 gene expression with APS treatment.
The concentration of APS administered was directly related to the improvement in muscle health observed.
Activation of the mTOR pathway in muscle cells indicates a promising therapeutic strategy for treating sarcopenia.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68d44f7b31b076d99fa56da3 https://doi.org/10.1177/09731296251367539

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Implication

Experimental analysis reveals that astragalus polysaccharide reduces reactive oxygen species in sarcopenic mice, suggesting a mechanism to enhance muscle protein levels.

Astragalus Polysaccharide Activates the AKT-mTOR Pathway to Reduce ROS and Promote Intramuscular Protein Levels in Sarcopenia Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Astragalus Polysaccharide Activates the AKT-mTOR Pathway to Reduce ROS and Promote Intramuscular Protein Levels in Sarcopenia Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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