Key result
Astragalus polysaccharide prevented fat wasting in heart failure-induced cachexia by inhibiting lipolysis and adipose browning in white adipose tissue and decreasing thermogenesis in brown adipose tissue.
Why the study?
Whether Astragalus polysaccharide regulates lipid metabolism in the context of cachexia remains unclear.
Does Astragalus polysaccharide prevent cachexia and improve cardiac function in a rat model of heart failure?
Population
Salt-sensitive hypertension-induced cardiac cachexia rat model
Comparison
Astragalus polysaccharide administration vs untreated heart failure cachexia model
Design
Preclinical animal study
Authors
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Hypothesis-generating for APS in rat HF cachexia; leaves open clinical translation.
Does Astragalus polysaccharide prevent cachexia and improve cardiac function in a rat model of heart failure?
p-value: p=<0.05
Astragalus polysaccharide prevents heart failure-induced cachexia by inhibiting lipolysis and adipose browning in white adipose tissue and decreasing thermogenesis in brown adipose tissue in a rat model.
Ma et al. (2023) studied Heart failure-induced cardiac cachexia (n=24). Astragalus polysaccharide vs. Pure water (Model group) was evaluated on Adipose expenditure (fat mass, lipolysis, browning in WAT, thermogenesis in BAT) (p=<0.05). Astragalus polysaccharide prevented fat wasting in heart failure-induced cachexia by inhibiting lipolysis and adipose browning in white adipose tissue and decreasing thermogenesis in brown adipose tissue.
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