Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 8, 2025Frontiers in Bioscience-LandmarkOpen Access

Astragalus Polysaccharide Improves Myocardial Fibrosis in Hypertrophic Cardiomyopathy Through the TGF-β1/Smad3 Signal Pathway

View Full Paper
Ask AI
Bookmark
Share

Authors

NQNana QinWWWenjun WuBLB Li

Discussion

Loading...

Member takes

Overview

Observational analysis revealed significant improvements in cardiac dysfunction and myocardial fibrosis with Astragalus polysaccharide, indicating potential in Hypertrophic Cardiomyopathy treatment.

Key Points

  • Myocardial fibrosis was significantly reduced in mice treated with Astragalus polysaccharide, suggesting a benefit to cardiac health.
  • Echocardiography showed improved cardiac function in the high-dose Astragalus group compared to control samples.
  • The analysis utilized a model of hypertrophic cardiomyopathy in C57BL/6J mice with transverse aortic constriction for assessment.
  • Findings highlight potential for Astragalus polysaccharide in addressing myocardial fibrosis through targeting relevant pathways.

Cite This Study

Qin et al. (2025) studied this question.

synapsesocial.com/papers/690e8b6ca5b062d7a4e73672https://doi.org/10.31083/fbl45595
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Astragalus polysaccharides alleviates cardiac hypertrophy in diabetic cardiomyopathy via inhibiting the BMP10-mediated signaling pathway2022 · 37 citations
  2. 2Therapeutic potential of astragalus polysaccharides in coronary heart disease: Insights into PCSK9/LDLR-mediated myocardial fibrosis2025
  3. 3Protection role of Astragalus polysaccharide against Cardiac injury in tnnt2a mutant Zebrafish model of Dilated Cardiomyopathy2023
  4. 4Astragalus polysaccharide protects against cardiac injury in a tnnt2a mutant zebrafish model of dilated cardiomyopathy2025 · 2 citations
  5. 5Astragalus polysaccharide prevents heart failure-induced cachexia by alleviating excessive adipose expenditure in white and brown adipose tissue2023 · 32 citations