Motivation: The physiology and function of slow flows in the brain parenchyma is poorly understood and remains an on-going research subject. Goal(s): To compare displacement fields of the simultaneous coherent and incoherent motion imaging (SCIMI) method (phase-based) and the 3D quantitative amplified MRI (q-aMRI) method (magnitude-based) with the view to jointly validate both methods. Approach: Displacement fields (Lagrangian perspective) of SCIMI and q-aMRI acquisitions were obtained from four healthy volunteers and compared using correlation and Bland Altman (BA) plots. Results: Correlation r2 as high as 0.93 and mean differences in BA analyses as low as 0 were observed between SCIMI and q-aMRI displacement estimations. Impact: This study independently compared the measured displacement fields due to brain parenchymal fluid flow obtained from the SCIMI and q-aMRI methods and the correlation of both estimations, thereby validating both methods and providing deeper insights for applications in neurodegenerative pathologies.
Ajala et al. (Tue,) studied this question.