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September 24, 2025BMC Neurology0 citationsOpen Access

Evaluating MoCA Sensitivity and Specificity in Cognitive Impairment Screening

Sensitivity and specificity of the Montreal cognitive assessment using U.S. National alzheimer coordinating centre uniform data set: a retrospective analysis of 16,309 participants

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Authors

YIYoussef A. IsmailHAHuda A. AufSSShahd A. Sadik

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Overview

Retrospective analysis assessed MoCA's diagnostic performance for dementia in 16,309 participants, indicating its reliability.

Key Points

  • MoCA demonstrated 83% sensitivity and 82% specificity for detecting dementia using a cutoff of 21.
  • ROC analysis yielded AUC values significantly above 0.5, underscoring MoCA’s strong diagnostic capability.
  • High negative predictive value of 94% shows MoCA's effectiveness in ruling out cognitive impairment.
  • Cutoff scores were optimized at < 24 for mild cognitive impairment and < 21 for dementia classifications.
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Ismail et al. (2025) studied this question.

synapsesocial.com/papers/68d6d8978b2b6861e4c3ee74https://doi.org/10.1186/s12883-025-04190-9
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