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September 24, 2025BMC NeurologyOpen Access

Sensitivity and specificity of the Montreal cognitive assessment using U.S. National alzheimer coordinating centre uniform data set: a retrospective analysis of 16,309 participants

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Authors

YIYoussef A. IsmailHAHuda A. AufSSShahd A. Sadik

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Overview

Retrospective analysis assessed MoCA's diagnostic performance for dementia in 16,309 participants, indicating its reliability.

Key Points

  • MoCA demonstrated 83% sensitivity and 82% specificity for detecting dementia using a cutoff of 21.
  • ROC analysis yielded AUC values significantly above 0.5, underscoring MoCA’s strong diagnostic capability.
  • High negative predictive value of 94% shows MoCA's effectiveness in ruling out cognitive impairment.
  • Cutoff scores were optimized at < 24 for mild cognitive impairment and < 21 for dementia classifications.

Cite This Study

Ismail et al. (2025) studied this question.

synapsesocial.com/papers/68d6d8978b2b6861e4c3ee74https://doi.org/10.1186/s12883-025-04190-9
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