Key result
Montreal Cognitive Assessment differentiates mild cognitive impairment from healthy controls with ~82% sensitivity.
Why the study?
The accuracy of MoCA subitems to differentiate healthy elderly from Mild Cognitive Impairment and Alzheimer's disease patients with more than four years of schooling was analyzed.
Does the Montreal Cognitive Assessment (MoCA) accurately differentiate Alzheimer's disease from mild cognitive impairment in elderly patients?
Cross-Sectional (n=136)
No
Does the Montreal Cognitive Assessment (MoCA) accurately differentiate Alzheimer's disease from mild cognitive impairment in elderly patients?
Effect estimate: Sensitivity 82.2%, Specificity 92.3%
The Montreal Cognitive Assessment is a highly sensitive and specific screening tool for differentiating Alzheimer's disease from mild cognitive impairment in educated elderly patients.
MoCA differentiates AD/MCI from controls in educated elderly; leaves open direct AD-MCI comparison and prospective validation.
The objective of this article is to analyze the accuracy of MoCA's subitems by comparing healthy elderly with Mild Cognitive Impaired and Alzheimer´s disease patients with more than four years of schooling.136 elderly, with 39 normal controls, 52 AD patients and 45 MCI treated at the Institute of Geriatrics and Gerontology were studied by means of Mini-Mental State Examination, Cambridge Cognitive Examination, Clock Drawing Test, Verbal Fluency test, Geriatric Depression Scale and Pfeffer Functional Activities Questionnaire.The results obtained by means of ROC curve showed that MoCA is a good screening test to differentiate elderly with Alzheimer's disease from mild cognitive impaired ones with 82.2% sensitivity and 92.3% specificity.Also, we perform an MANOVA and the results suggest significant differences between the three studied groups.We concluded that MoCA is a good screening instrument to assess mild cognitive impairment and Alzheimer´s disease in elderly with more than 4 years of schooling.
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Cecato et al. (2014) conducted a cross-sectional in Mild Cognitive Impairment and Alzheimer's disease (n=136). Montreal Cognitive Assessment (MoCA) vs. Healthy controls was evaluated on Differentiation of mild cognitive impairment from healthy controls (Sensitivity 82.2%, Specificity 92.3%). The Montreal Cognitive Assessment effectively differentiated mild cognitive impairment from healthy controls with 82.2% sensitivity and 92.3% specificity (AUC 0.94), and Alzheimer's disease from controls with 98.1% sensitivity and 100% specificity (AUC 0.99).
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